optimized the combination from Oct3/4, Sox2, c-Myc, Klf4 to Oct4, Sox2, NANOG, LIN28, and successfully produced pluripotent stem cells in 2007 ( 7). The same chemical factors successfully transformed human fibroblasts into pluripotent stem cells ( 6). Shinya Yamanaka pioneered the development of induced pluripotent stem cells in 2006, using a combination of Oct3/4, Sox2, c-Myc, and Klf4 to convert mouse fibroblasts into pluripotent stem cells ( 5). Somatic cell nuclear transfer is the early way to create pluripotent stem cells, by which the cloned sheep, Dolly, was born ( 4). Stem cells can be classified as totipotent stem cells (fertilized eggs), pluripotent stem cells (embryonic stem cells), multipotent stem cells (mesenchymal stem cells), and unipotent stem cells (basal cells) by the differentiation potency. Adult stem cells, including hematopoietic stem cells, basal skin cells, and mesenchymal stem cells, are located in specific ecological niches in the body, like bone marrow and gonads, which can differentiate into several kinds of somatic cells ( 3). Pluripotent stem cells exist in blastocysts with 50–150 cells in mammals and differentiate into all cell types required by the body during growth and development, called embryonic stem cells ( 2). Fertilized eggs belong to totipotent stem cells. Stem cells are undifferentiated or partially differentiated cells with the ability to self-renew and multiple differentiation ( 1). This research field is developing, and a deeper exploration of 3D patient-specific organoid disease models is worth more research in the future. “ precision medicine” ( n = 89, 12.64%), “personalized medicine” ( n = 72, 10.23%), “stem cells” ( n = 43, 4.40%), and “induced pluripotent stem cells” ( n = 41, 5.82%), “cancer stem cells” ( n = 31, 4%), “organoids” ( n = 26, 3.69%) were the top 6 frequent keywords.Ĭonclusion: The present study performs a comprehensive investigation concerning stem cell precision medicine (2018–2022) for the first time. The most cited document was entitled “Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling and Precision Medicine: A Scientific Statement From the American Heart Association” with 9 times local citations. NATURE was the most co-cited journal with 1860 times citations. CANCERS was considered the most productive journal with 18 documents. International academic collaborations were active. The United States contributed the most publications (160, 29.0%) to the field, followed by China (63, 11.4%) and Italy (60, 10.9%). Annual publication outputs trended upward and reached a peak of 172 in 2021. Results: A total of 552 publications were retrieved from 2018 to 2022. Methods: A literature search of stem cell precision medicine research from 2018 to 2022 was carried out using the Web of Science Core Collection.VOSviewer, R-bibliometrix, and CiteSpace software programs were employed to perform the bibliometric analysis. Bibliometric analysis is an efficient way to quickly understand global trends and hotspots in this field. Based on the construction of 3D, patient-specific disease models from pluripotent induced stem cells, proper research on disease development and treatment prognosis can be realized. Disease models are mainly established by induced pluripotent stem cells, and the research of stem cell precision medicine has been promising in recent years. Stem cell therapy can be summarized into three aspects (regenerative treatment, therapy targeted at stem cells, and establishment of disease models). Shinya Yamanaka first discovered a method to convert somatic cells into pluripotent stem cells in 2006. Department of Burn Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Chinaīackground: Stem cells are a group of cells that can self-renew and have multiple differentiation capabilities.
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